FXR agonist 3
FXR agonist 3 is an anti-NASH agent, acting by activating FXR. FXR agonist 3 inhibits COL1A1, TGF-β1, α-SMA and TIMP1 expression with anti-fibrogenic activity. FXR agonist 3 significantly reduces liver steatosis and inflammation, improves liver fibrosis level[1].
Product Specifications
CAS Number
[3037847-72-3]
UNSPSC
12352005
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fxr-agonist-3.html
Concentration
10mM
Purity
96.51
Solubility
DMSO : ≥ 250 mg/mL
Smiles
COC1=C(C=C2C(CC[N+]3=C2C=C4C=CC(OC)=C(C4=C3)OCC5=CC(C)=CC=C5)=C1)OC.[Br-]
Molecular Formula
C28H28BrNO4
Molecular Weight
522.43
References & Citations
[1]Zhang N, et al. Discovery and development of palmatine analogues as anti-NASH agents by activating farnesoid X receptor (FXR) . Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114886.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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