LY2979165
LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist[1].
Product Specifications
CAS Number
1311385-32-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LY2979165.html
Purity
99.30
Solubility
DMSO : < 1 mg/mL|H2O : ≥ 50 mg/mL
Smiles
[H][C@]12[C@](C(O)=O)(C[C@H]([C@]1([C@@H]2C(O)=O)[H])SC3=NN=CN3)NC([C@H](C)N)=O.N.O
Molecular Formula
C13H22N6O6S
Molecular Weight
390.42
Precautions
H315, H319, H335
References & Citations
[1]Juliet McColm , et al. Evaluation of Single and Multiple Doses of a Novel mGlu2 Agonist, a Potential Antipsychotic Therapy, in Healthy Subjects. Br J Clin Pharmacol. 2017 Aug;83 (8) :1654-1667.|[2]Mitul A Mehta, et al. Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects. Psychopharmacology (Berl) . 2018 Jul;235 (7) :1875-1886.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MGluR2
Available Sizes
Frequently Asked Questions
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