LY2979165

LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist[1].

Product Specifications

CAS Number

[1311385-32-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/LY2979165.html

Purity

99.30

Solubility

DMSO : < 1 mg/mL|H2O : ≥ 50 mg/mL

Smiles

[H][C@]12[C@](C(O)=O)(C[C@H]([C@]1([C@@H]2C(O)=O)[H])SC3=NN=CN3)NC([C@H](C)N)=O.N.O

Molecular Formula

C13H22N6O6S

Molecular Weight

390.42

Precautions

H315, H319, H335

References & Citations

[1]Juliet McColm , et al. Evaluation of Single and Multiple Doses of a Novel mGlu2 Agonist, a Potential Antipsychotic Therapy, in Healthy Subjects. Br J Clin Pharmacol. 2017 Aug;83 (8) :1654-1667.|[2]Mitul A Mehta, et al. Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects. Psychopharmacology (Berl) . 2018 Jul;235 (7) :1875-1886.