Quinizarin

Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM) . Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth[1][2].

Product Specifications

CAS Number

[81-64-1]

Product Name Alternative

1,4-Dihydroxyanthraquinone

UNSPSC

12171500

Hazard Statement

H410

Target

DNA/RNA Synthesis; Fungal

Type

Dye Reagents

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/quinizarin.html

Purity

98.84

Solubility

DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(C=CC=C2)C(C3=C(O)C=CC(O)=C13)=O

Molecular Formula

C14H8O4

Molecular Weight

240.21

Precautions

H410

References & Citations

[1]Verebová V, et al. Anthraquinones quinizarin and danthron unwind negatively supercoiled DNA and lengthen linear DNA. Biochem Biophys Res Commun. 2014;444 (1) :50-55.|[2]Dominic Cheuk, et al. Investigation into solid and solution properties of quinizarin.|[3]Wang M, et al. Electrospun 1,4-DHAQ-doped cellulose nanofiber films for reusable fluorescence detection of trace Cu2+ and further for Cr3+. Environ Sci Technol. 2012;46 (1) :367-373.