Vitamin K5 (hydrochloride)

Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages[1][2][3].

Product Specifications

CAS Number

[130-24-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bacterial; Fungal; Pyruvate Kinase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/vitamin-k5-hydrochloride.html

Purity

99.25

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=C2C=CC=CC2=C(N)C=C1C.[H]Cl

Molecular Formula

C11H12ClNO

Molecular Weight

209.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Xu F, et al. Vitamin K5 is an efficient photosensitizer for ultraviolet A light inactivation of bacteria. FEMS Microbiol Lett. 2018 Feb 1;365 (4) .|[2]Chen J, et al. Vitamin K (3) and K (5) are inhibitors of tumor pyruvate kinase M2. Cancer Lett. 2012 Mar 28;316 (2) :204-10.|[3]Ogawa M, et al. Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells. Int J Oncol. 2007 Aug;31 (2) :323-31.