(-) -Epicatechin

(-) -Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-) -Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

Product Specifications

CAS Number

[490-46-0]

Product Name Alternative

(-) -Epicatechol; Epicatechin; epi-Catechin

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

COX; Endogenous Metabolite; Ferroptosis

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/_-_-Epicatechin.html

Purity

99.00

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1

Molecular Formula

C15H14O6

Molecular Weight

290.27

Precautions

H315, H319, H335

References & Citations

[1]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40 (2) :173-9.|[2]Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-) -Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260.|[3]Nogueira L, et al. (-) -Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589 (Pt 18) :4615-31.