Dimethyl 2-oxoglutarate

Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate) is a cell-permeable derivative of 2-oxoglutarate and tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate inhibits Autophagy. Dimethyl 2-oxoglutarate prevents mitochondrial damage and reduces ROS production. Dimethyl 2-oxoglutarate alleviates Carbon tetrachloride (HY-Y0298) -induced liver fibrosis. Dimethyl-2-oxoglutaric acid can be used in the research of diseases such as Alzheimer's disease, diabetes, and cardiomyopathy[1][2][3][4].

Product Specifications

CAS Number

[13192-04-6]

Product Name Alternative

Dimethyl α-ketoglutarate

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Drug Derivative; Endogenous Metabolite; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Type

Biochemical Assay Reagents

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dimethyl-2-oxoglutarate.html

Purity

97.50

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(OC)C(CCC(OC)=O)=O

Molecular Formula

C7H10O5

Molecular Weight

174.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Faulkner A, et al. Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus. Diabetologia. 2020 Oct;63 (10) :2205-2217.|[2]Mariño G, et al. Dimethyl α-ketoglutarate inhibits maladaptive autophagy in pressure overload-induced cardiomyopathy. Autophagy. 2014 May;10 (5) :930-2. |[3]Zhao J, et al. Dimethyl α-ketoglutarate reduces CCl4-induced liver fibrosis through inhibition of autophagy in hepatic stellate cells. Biochem Biophys Res Commun. 2016 Dec 2;481 (1-2) :90-96.|[4]Chauhan A, et al. Dimethyl-2-oxoglutarate but not antioxidants prevents glucose hypometabolism induced neural cell death: implications in the pathogenesis and therapy of Alzheimer's disease. Biochem Biophys Rep. 2025 Jul 12;43:102150.