JKE-1716
Product Specifications
UNSPSC Description
JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition[1].
Target Antigen
Ferroptosis; Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/jke-1716.html
Smiles
O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C/C([N+]([O-])=O)=N/O
Molecular Weight
451.30
References & Citations
[1]Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020;16(5):497-506.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139001/JKE-1716-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139001/JKE-1716-SDS-MedChemExpress.pdf
CAS Number
2421118-05-8
Available Sizes
Curated Selection
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