JKE-1716

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition[1].

Product Specifications

CAS Number

[2421118-05-8]

UNSPSC

12352005

Target

Ferroptosis; Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/jke-1716.html

Purity

98.04

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C/C([N+]([O-])=O)=N/O

Molecular Formula

C20H20Cl2N4O4

Molecular Weight

451.30

References & Citations

[1]Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020;16 (5) :497-506.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GPX4

Available Sizes

Curated Selection

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