Polyketomycin
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 μg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].
Product Specifications
CAS Number
200625-47-4
UNSPSC
12352005
Target
ADC Payload; Antibiotic; Bacterial; Parasite
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/polyketomycin.html
Solubility
10 mM in DMSO
Smiles
O[C@]1([C@@H]2O[C@]3([H])O[C@@H]([C@@H](O[C@@]4([H])C[C@@](O)([C@H](OC(C5=C(C(C)=CC=C5C)O)=O)[C@H](C)O4)C)CC3)C)[C@](C(C6=C(C(C)=C7C(C(C=C(OC)C7=O)=O)=C6O)C1)=O)(C(/C(C2=O)=C(O)\C)=O)O
Molecular Formula
C44H48O18
Molecular Weight
864.84
References & Citations
[1]Momose I, et al. Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo) . 1998 Jan;51 (1) :21-5.|[2]Daum M, et al. Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem. 2009 Apr 17;10 (6) :1073-83.|[3]Otoguro K, In vitro antimalarial activities of the microbial metabolites. J Antibiot (Tokyo) . 2003 Mar;56 (3) :322-4.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium; Traditional Cytotoxic Agents
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