HG-10-102-01

HG-10-102-01 is a highly potent, selective, and brain-penetrable LRRK2 inhibitor, with IC50 values of 20.3 and 3.2 nM against wild-type LRRK2 and LRRK2[G2019S], respectively. HG-10-102-01 also inhibits MNK2 and MLK1, with IC50 values of 0.6 and 2.1 μM. HG-10-102-01 can be used for Parkinson's disease (PD) research[1][2].

Product Specifications

CAS Number

[1351758-81-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

LRRK2; MNK

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/HG-10-102-01.html

Purity

99.55

Solubility

DMSO : ≥ 50 mg/mL

Smiles

COC1=CC(C(N2CCOCC2)=O)=CC=C1NC3=NC(NC)=C(Cl)C=N3

Molecular Formula

C17H20ClN5O3

Molecular Weight

377.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Choi HG, et al. Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 2012 Aug 9;3 (8) :658-662.|[2]Wang M, et al. Synthesis of [11C]HG-10-102-01 as a new potential PET agent for imaging of LRRK2 enzyme in Parkinson's disease. Bioorg Med Chem Lett. 2017 Mar 15;27 (6) :1351-1355.