Cerberin
Cerberin is a cardiac glycoside that has been found in C. odollam and has cytotoxic and cardiac modulatory activities. It is cytotoxic to KB and NCI H187 cancer cells (IC50s=1.92 and 1.24 μg/mL) .1 Cerberin inhibits Na+/K+-ATPase, increasing intracellular sodium levels and action potential duration in cardiac cells.
Product Specifications
CAS Number
[25633-33-4]
Product Name Alternative
2'-Acetylneriifolin
UNSPSC
12352005
Target
Na+/K+ ATPase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cerberin.html
Purity
98.0
Smiles
O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(CO4)=CC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O)OC)OC(C)=O)([H])CC3)C
Molecular Formula
C32H48O9
Molecular Weight
576.72
References & Citations
[1]Laphookhieo, et al. Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam. Phytochemistry 65 (4), 507-510 (2004) .
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W779529/Cerberin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W779529/Cerberin-SDS-MedChemExpress.pdf
Scientific Category
Natural Products
Clinical Information
No Development Reported
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