Amiodarone (hydrochloride) (Standard)

Amiodarone (hydrochloride) (Standard) is the analytical standard of Amiodarone (hydrochloride) . This product is intended for research and analytical applications. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].

Product Specifications

CAS Number

[19774-82-4]

UNSPSC

12352005

Hazard Statement

H312, H332, H350, H360

Target

Autophagy; Potassium Channel; Reference Standards

Type

Reference Standards

Related Pathways

Autophagy; Membrane Transporter/Ion Channel; Others

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/amiodarone-hydrochloride-standard.html

Purity

99.91

Solubility

DMSO : 24.5 mg/mL (ultrasonic; warming)

Smiles

CCCCC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=C(O1)C=CC=C3.Cl

Molecular Formula

C25H30ClI2NO3

Molecular Weight

681.77

Precautions

H312, H332, H350, H360

References & Citations

[1]Yihong Zhang, et al. Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking. Biochem Pharmacol. 2016 Aug 1;113:24-35.|[2]Sabrina Le Bouter, et al. Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation. 2004 Nov 9;110 (19) :3028-35.|[3]Jie Weng, et al. Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Biomed Pharmacother. 2019 Jul;115:108889.