Triciribine

Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.

Product Specifications

CAS Number

[35943-35-2]

Product Name Alternative

API-2; NSC 154020; TCN

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Akt; DNA/RNA Synthesis; HIV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Triciribine.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C3=NC=NC4=C3C(C(N)=NN4C)=C2

Molecular Formula

C13H16N6O4

Molecular Weight

320.30

Precautions

H317, H319

References & Citations

[1]Dieterle A, et al. The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. Int J Cancer. 2009 Aug 15;125 (4) :932-41.|[2]Gürsel DB, et al. Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma. Neuro Oncol. 2011 Jun;13 (6) :610-21|[3]Kucera LS, et al. Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2. AIDS Res Hum Retroviruses. 1993 Apr;9 (4) :307-14.|[4]Abdalla M, et al. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis. Br J Pharmacol. 2015 Aug;172 (16) :4173-88.