Triciribine
Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
Product Specifications
CAS Number
35943-35-2
Product Name Alternative
API-2; NSC 154020; TCN
UNSPSC
12352005
Hazard Statement
H317, H319
Target
Akt; DNA/RNA Synthesis; HIV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Triciribine.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C3=NC=NC4=C3C(C(N)=NN4C)=C2
Molecular Formula
C13H16N6O4
Molecular Weight
320.30
Precautions
H317, H319
References & Citations
[1]Dieterle A, et al. The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. Int J Cancer. 2009 Aug 15;125 (4) :932-41.|[2]Gürsel DB, et al. Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma. Neuro Oncol. 2011 Jun;13 (6) :610-21|[3]Kucera LS, et al. Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2. AIDS Res Hum Retroviruses. 1993 Apr;9 (4) :307-14.|[4]Abdalla M, et al. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis. Br J Pharmacol. 2015 Aug;172 (16) :4173-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Akt; HIV-1; HIV-2
Available Sizes
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