HECT E3-IN-1
HECT E3-IN-1 (compound 3) is a HECT E3 ligase inhibitor. HECT E3-IN-1 (compound 3) disrupts Ub binding to the noncovalent Ub-binding site of Nedd4-1[1].
Product Specifications
CAS Number
[1810058-52-6]
UNSPSC
12352005
Hazard Statement
H301-H311-H331-H341
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hect-e3-in-1.html
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C(NC/C=C/C(OC)=O)=O)C2=CC(OC)=CC=C2N1C3CCCC3
Molecular Formula
C21H26N2O4
Molecular Weight
370.44
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
References & Citations
[1]Stefan G Kathman, et al. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J Am Chem Soc. 2015 Oct 7;137 (39) :12442-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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