HECT E3-IN-1
Product Specifications
UNSPSC Description
HECT E3-IN-1 (compound 3) is a HECT E3 ligase inhibitor. HECT E3-IN-1 (compound 3) disrupts Ub binding to the noncovalent Ub-binding site of Nedd4-1[1].
Target Antigen
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hect-e3-in-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C(NC/C=C/C(OC)=O)=O)C2=CC(OC)=CC=C2N1C3CCCC3
Molecular Weight
370.44
References & Citations
[1]Stefan G Kathman, et al. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J Am Chem Soc. 2015 Oct 7;137(39):12442-5.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153178/HECT-E3-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153178/HECT-E3-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1810058-52-6
Available Sizes
Curated Selection
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