HECT E3-IN-1

HECT E3-IN-1 (compound 3) is a HECT E3 ligase inhibitor. HECT E3-IN-1 (compound 3) disrupts Ub binding to the noncovalent Ub-binding site of Nedd4-1[1].

Product Specifications

CAS Number

[1810058-52-6]

UNSPSC

12352005

Hazard Statement

H301-H311-H331-H341

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/hect-e3-in-1.html

Purity

99.43

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(C(NC/C=C/C(OC)=O)=O)C2=CC(OC)=CC=C2N1C3CCCC3

Molecular Formula

C21H26N2O4

Molecular Weight

370.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

References & Citations

[1]Stefan G Kathman, et al. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J Am Chem Soc. 2015 Oct 7;137 (39) :12442-5.