ZCAN262
ZCAN262 (compound 6) is an AMPA modulator. ZCAN262 prevents AMPA-mediated excitotoxicity by targeting an allosteric binding site[1].
Product Specifications
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zcan262.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CN(C(C1=NC(N2CC3=CN(N=C3C2)CC4=CC=C(C=C4F)F)=NC=C1)=O)C
Molecular Formula
C19H18F2N6O
Molecular Weight
384.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Dongxu Zhai, et al. Small-molecule targeting AMPA-mediated excitotoxicity has therapeutic effects in mouse models for multiple sclerosis. Sci Adv. 2023, 9, 49.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Available Sizes
Curated Selection
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