Aegeline
Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].
Product Specifications
CAS Number
456-12-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fungal
Type
Natural Products
Related Pathways
Anti-infection
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aegeline.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC(O)C1=CC=C(OC)C=C1)/C=C/C2=CC=CC=C2
Molecular Formula
C18H19NO3
Molecular Weight
297.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Derf A, et al. a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast [published correction appears in Bioorg Med Chem Lett. 2019 Aug 15;29 (16) :2437-2438]. Bioorg Med Chem Lett. 2019;29 (3) :454‐460.|[2]Nugroho AE, et al. Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells. Pak J Pharm Sci. 2011;24 (3) :359‐367.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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