Aegeline

Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].

Product Specifications

CAS Number

[456-12-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fungal

Type

Natural Products

Related Pathways

Anti-infection

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aegeline.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCC(O)C1=CC=C(OC)C=C1)/C=C/C2=CC=CC=C2

Molecular Formula

C18H19NO3

Molecular Weight

297.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Derf A, et al. a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast [published correction appears in Bioorg Med Chem Lett. 2019 Aug 15;29 (16) :2437-2438]. Bioorg Med Chem Lett. 2019;29 (3) :454‐460.|[2]Nugroho AE, et al. Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells. Pak J Pharm Sci. 2011;24 (3) :359‐367.