FLT3/CHK1-IN-1

FLT3/CHK-IN-1 (Compound 18) is a dual inhibitor of FLT3/CHK1. FLT3/CHK-IN-1 is more than 1700 times more selective to c-KI T and greatly reduces hERG affinity with an IC50 value of 58.4 μM. FLT3/CHK-IN-1 inhibits tumor growth in mouse xenotransplantation models inoculated with MV-4-11 cells[1].

Product Specifications

CAS Number

[2991054-23-8]

UNSPSC

12352005

Target

FLT3

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/flt3-chk1-in-1.html

Purity

98.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N[C@H]1CC[C@@H](NC2=NC(NC3=CC4=C(C=C3)CN(C(CC(O)(C)C)=O)CC4)=NC=C2C(F)(F)F)CC1

Molecular Formula

C25H33F3N6O2

Molecular Weight

506.56

References & Citations

[1]Li X, et al. Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities. J Med Chem. 2023 Sep 14;66 (17) :11792-11814.