GNE-1858
GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively[1].
Product Specifications
CAS Number
[2680616-96-8]
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gne-1858.html
Purity
99.23
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
FC1(CCN(C2=NC(C3CCNC3)=CC(NC4=CC5=C(C=N4)C=NN5C(C)C)=N2)C1)F
Molecular Formula
C21H26F2N8
Molecular Weight
428.48
References & Citations
[1]Wu P, et al. Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure. 2019 Jan 2;27 (1) :125-133.e4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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