Posaconazole
Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
Product Specifications
CAS Number
171228-49-2
Product Name Alternative
SCH 56592
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fungal; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Posaconazole.html
Purity
99.95
Solubility
DMSO : 18.75 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC=C([C@@]2(CN3C=NC=N3)C[C@H](COC4=CC=C(N5CCN(C6=CC=C(N7C=NN([C@@H](CC)[C@H](C)O)C7=O)C=C6)CC5)C=C4)CO2)C(F)=C1
Molecular Formula
C37H42F2N8O4
Molecular Weight
700.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Benaim G, et al. Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. J Med Chem. 2006 Feb 9;49 (3) :892-9.|[2]Sabatelli F, et al. In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts. Antimicrob Agents Chemother. 2006 Jun;50 (6) :2009-15.|[3]Sansone-Parsons A, et al. Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers. Antimicrob Agents Chemother. 2006 May;50 (5) :1881-3.|[4]Veiga-Santos P, et al. Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi. Int J Antimicrob Agents. 2012 Jul;40 (1) :61-71.|[5]Sun QN, et al. In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model. Antimicrob Agents Chemother. 2002 Jul;46 (7) :2310-2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
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