Cimetidine sulfoxide

Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment[1].

Product Specifications

CAS Number

[54237-72-8]

Product Name Alternative

Cimetidine sulphoxide

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cimetidine-sulfoxide.html

Purity

97.0

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=S(CC/N=C(NC)/NC#N)CC1=C(C)N=CN1

Molecular Formula

C10H16N6OS

Molecular Weight

268.35

Precautions

H301, H311, H331

References & Citations

[1] Larsson R, et al. The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function. Br J Clin Pharmacol. 1982;13 (2) :163-170.|[2]HE Barber, et al. The Transport of Cimetidine Across the Rat Small Intestine in Vitro. B r J Pharmacol. 1979 Jul;66 (3) :496P-497P.|[3] Ryta A. Kuzel, et al. Investigations into the chirality of the metabolic sulfoxidation of cimetidine. Chirality (1994), 6 (8), 607-14.