Rusfertide

Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis[1][2].

Product Specifications

CAS Number

[1628323-80-7]

Product Name Alternative

PTG-300

UNSPSC

12352209

Target

Ferroportin; Hepcidin

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/rusfertide.html

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(C)CC(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CN=CN1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N[C@@H]4C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@](CCC5)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CSSC4)C(N[C@H](C(N)=O)CCCCN)=O)=O)=O)CCCCN)=O)CO)=O)CCCNC(N)=N)=O)=O)CCC(O)=O)=O)CC6=CC=CC=C6)=O)CCCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCC)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C114H181N27O28S2

Molecular Weight

2441.95

References & Citations

[1]Taranath R, et al., Regulation of iron homeostasis by PTG-300 improves disease parameters in mouse models for beta-thalassemia and hereditary hemochromatosis[J]. Blood, 2019, 134: 3540.|[2]Kremyanskaya M, et al., PTG-300 eliminates the need for therapeutic phlebotomy in both low and high-risk polycythemia vera patients[J]. Blood, 2020, 136: 33-35.