Rusfertide
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis[1][2].
Product Specifications
CAS Number
1628323-80-7
Product Name Alternative
PTG-300
UNSPSC
12352209
Target
Ferroportin; Hepcidin
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rusfertide.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C)CC(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CN=CN1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N[C@@H]4C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@](CCC5)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CSSC4)C(N[C@H](C(N)=O)CCCCN)=O)=O)=O)CCCCN)=O)CO)=O)CCCNC(N)=N)=O)=O)CCC(O)=O)=O)CC6=CC=CC=C6)=O)CCCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCC)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C114H181N27O28S2
Molecular Weight
2441.95
References & Citations
[1]Taranath R, et al., Regulation of iron homeostasis by PTG-300 improves disease parameters in mouse models for beta-thalassemia and hereditary hemochromatosis[J]. Blood, 2019, 134: 3540.|[2]Kremyanskaya M, et al., PTG-300 eliminates the need for therapeutic phlebotomy in both low and high-risk polycythemia vera patients[J]. Blood, 2020, 136: 33-35.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6421174-01 0.1 mL
HNF4A, Phosphorylated (S304) (Hepatocyte Nuclear Factor 4 Alpha, TCF, HNF4, MODY, MODY1, NR2A1, TCF14, HNF4a7, HNF4a8, HNF4a9, NR2A21, HNF4alpha) (Biotin)
Sign In for Pricing
View Details MBS6421174-02 5x 0.1 mL
HNF4A, Phosphorylated (S304) (Hepatocyte Nuclear Factor 4 Alpha, TCF, HNF4, MODY, MODY1, NR2A1, TCF14, HNF4a7, HNF4a8, HNF4a9, NR2A21, HNF4alpha) (Biotin)
Sign In for Pricing
View Details 
