JBSNF-000028 (free base)

JBSNF-00002 free base is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 free base can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 free base exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 free base can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease[1].

Product Specifications

CAS Number

[3026599-90-3]

UNSPSC

12352005

Target

Amine N-methyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/jbsnf-000028.html

Purity

99.20

Solubility

DMSO : 60 mg/mL (ultrasonic)

Smiles

CN1CC2=C3C(CCN3C1=N)=CC=C2

Molecular Formula

C11H13N3

Molecular Weight

187.24

References & Citations

[1]Ruf S, et al. Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2022 Sep 14;12 (1) :15440.