XL-281
XL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity[1].
Product Specifications
CAS Number
[870603-16-0]
Product Name Alternative
BMS-908662
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xl-281.html
Smiles
O=C(OC)NC1=NC2=CC=C(C3(O)N(C4=CC(Cl)=CC=C4C)C(C5=C3C=CC=C5)=O)C=C2N1
Molecular Formula
C24H19ClN4O4
Molecular Weight
462.89
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Dickson MA, et al., Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33 (2) :349-56.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
B-Raf; C-Raf
Available Sizes
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