SAR441255 (TFA)

SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors. SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys[1].

Product Specifications

UNSPSC

12352209

Target

GCGR; GLP Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sar441255-tfa.html

Purity

99.93

Solubility

DMSO : 66.67 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(O)[C@H](CCC(N[C@H](C(O)=O)CCC(NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC(C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(NCC(N1[C@H](C(N2[C@H](C(N[C@H](C(NC(C)(C(N[C@H](C(N3[C@H](C(N4[C@H](C(N5[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCC5)=O)CCC4)=O)CCC3)=O)CCCCN)=O)C)=O)CO)=O)CCC2)=O)CCC1)=O)=O)C)=O)C)=O)CCCCN)=O)CC(C)C)=O)CC6=CNC7=CC=CC=C67)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CC8=CC=CC=C8)=O)CCC(O)=O)=O)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@@H](C)O)NC([C@H](CC9=CC=CC=C9)NC([C@H]([C@@H](C)O)NC(CNC([C@H](CC%10=CNC=N%10)NC(C(C)(C)NC([C@@H](N)CC%11=CNC=N%11)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(CCCCCCCCCCCCCCC)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C225H355N57O63.xC2HF3O2

Molecular Weight

4866.56 (free base)

References & Citations

[1]Martin Bossart, et al. Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. Cell Metab. 2022 Jan 4;34 (1) :59-74.e10.