Iseganan
Iseganan is an anti-microbial peptide that is active against both Gram-positive and Gram-negative bacteria and fungi. Iseganan kills a broad-spectrum of bacteria and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research[1][2][3].
Product Specifications
CAS Number
257277-05-7
Product Name Alternative
IB-367
UNSPSC
12352209
Target
Bacterial; Fungal; Parasite
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/iseganan.html
Purity
98.87
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@]1([H])C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N2)=O)NC([C@H](CC(C)C)NC(CNC(CNC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)C(C)C)=O)([H])CSSC1)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)[C@@H]2CC4=CC=C(C=C4)O
Molecular Formula
C78H126N30O18S4
Molecular Weight
1900.28
References & Citations
[1]Toney JH. Iseganan (IntraBiotics pharmaceuticals) . Curr Opin Investig Drugs. 2002 Feb;3 (2) :225-8.|[2]Giles FJ, et al. Iseganan HCl: a novel antimicrobial agent. Expert Opin Investig Drugs. 2002 Aug;11 (8) :1161-70.|[3]Landa A, et al. Antimicrobial peptides (Temporin A and Iseganan IB-367) : effect on the cysticerci of Taenia crassiceps. Mol Biochem Parasitol. 2009 Apr;164 (2) :126-30.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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