Iseganan

Iseganan is an anti-microbial peptide that is active against both Gram-positive and Gram-negative bacteria and fungi. Iseganan kills a broad-spectrum of bacteria and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research[1][2][3].

Product Specifications

CAS Number

[257277-05-7]

Product Name Alternative

IB-367

UNSPSC

12352209

Target

Bacterial; Fungal; Parasite

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/iseganan.html

Purity

98.87

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@]1([H])C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N2)=O)NC([C@H](CC(C)C)NC(CNC(CNC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)C(C)C)=O)([H])CSSC1)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)[C@@H]2CC4=CC=C(C=C4)O

Molecular Formula

C78H126N30O18S4

Molecular Weight

1900.28

References & Citations

[1]Toney JH. Iseganan (IntraBiotics pharmaceuticals) . Curr Opin Investig Drugs. 2002 Feb;3 (2) :225-8.|[2]Giles FJ, et al. Iseganan HCl: a novel antimicrobial agent. Expert Opin Investig Drugs. 2002 Aug;11 (8) :1161-70.|[3]Landa A, et al. Antimicrobial peptides (Temporin A and Iseganan IB-367) : effect on the cysticerci of Taenia crassiceps. Mol Biochem Parasitol. 2009 Apr;164 (2) :126-30.