Palosuran
Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats[1][2].
Product Specifications
CAS Number
540769-28-6
Product Name Alternative
ACT-058362
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Urotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Palosuran.html
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(CC1=CC=CC=C1)(CC2)CCN2CCNC(NC3=CC(C)=NC4=CC=CC=C34)=O
Molecular Formula
C25H30N4O2
Molecular Weight
418.53
Precautions
H315, H319, H335
References & Citations
[1]Clozel M, et al. Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2- (4-benzyl-4-hydroxy-piperidin-1-yl) -ethyl]-3- (2-methyl-quinolin-4-yl) -urea sulfate salt) : first demonstration of a pathophysiological role of the urotensin System. J Pharmacol Exp Ther. 2004 Oct;311 (1) :204-12.|[2]Clozel M, et al. The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats. J Pharmacol Exp Ther. 2006 Mar;316 (3) :1115-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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