Disufenton sodium

Disufenton sodium (NXY-059) scavenges free radicals, reduces ischemic damage and exhibits neuroprotective effects[1].

Product Specifications

CAS Number

[168021-79-2]

Product Name Alternative

NXY-059

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nxy-059.html

Purity

99.97

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 50 mg/mL

Smiles

O=S(C1=C(C=CC(S(=O)(O[Na])=O)=C1)/C=[N+]([O-])/C(C)(C)C)(O[Na])=O

Molecular Formula

C11H13NNa2O7S2

Molecular Weight

381.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Kuroda S, et al. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab, 1999, 19 (7), 778-787.|[2]Marshall JW, et al. NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke, 2001, 32 (1), 190-198.|[3]Culot M, et al. Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study. Brain Res, 2009, 19 (1294), 144-152.