Disufenton sodium
Disufenton sodium (NXY-059) scavenges free radicals, reduces ischemic damage and exhibits neuroprotective effects[1].
Product Specifications
CAS Number
168021-79-2
Product Name Alternative
NXY-059
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nxy-059.html
Purity
99.97
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 50 mg/mL
Smiles
O=S(C1=C(C=CC(S(=O)(O[Na])=O)=C1)/C=[N+]([O-])/C(C)(C)C)(O[Na])=O
Molecular Formula
C11H13NNa2O7S2
Molecular Weight
381.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Kuroda S, et al. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab, 1999, 19 (7), 778-787.|[2]Marshall JW, et al. NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke, 2001, 32 (1), 190-198.|[3]Culot M, et al. Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study. Brain Res, 2009, 19 (1294), 144-152.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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