Chlopynostat
Chlopynostat (Compound 6c) is a HDAC1 inhibitor with a IC50 value of 67 nM. Chlopynostat reverses STAT4/p66Shc defects by inhibiting HDAC1-induced Apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chlopynostat.html
Purity
98.36
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(CC2=CC=C(C(NC3=CC=CC=C3N)=O)C=C2)C=NC4=CC(Cl)=CC=C41
Molecular Formula
C22H17ClN4O2
Molecular Weight
404.85
References & Citations
[1]Rossi S, et al. A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients. Biomed Pharmacother. 2024 Apr 4;174:116537.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1
Available Sizes
Frequently Asked Questions
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