Remdesivir nucleoside monophosphate

Remdesivir nucleoside monophosphate is a metabolite of Remdesivir (HY-104077) . Remdesivir is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection[1][2][3].

Product Specifications

CAS Number

[1911578-74-9]

UNSPSC

12352005

Target

DNA/RNA Synthesis; Drug Metabolite; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/remdesivir-nucleoside-monophosphate.html

Purity

99.98

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@@H](O)[C@](C#N)(C2=CC=C3C(N)=NC=NN32)O[C@@H]1COP(O)(O)=O

Molecular Formula

C12H14N5O7P

Molecular Weight

371.24

References & Citations

[1]Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9 (2) . pii: e00221-18.|[2]Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30 (3) :269-271.|[3]Hu H, et al. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity. J Med Chem. 2022 Sep 22;65 (18) :12044-12054.