2-Hydroxycinnamaldehyde
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities[1][2][3].
Product Specifications
CAS Number
3541-42-2
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; STAT; Wnt; β-catenin
Type
Natural Products
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-hydroxycinnamaldehyde.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=CC=CC1=C(O)C=CC=C1
Molecular Formula
C9H8O2
Molecular Weight
148.16
Precautions
H315, H319
References & Citations
[1]Lee MA, et al. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling. J Nat Prod. 2013 Jul 26;76 (7) :1278-84.|[2]Yoon YJ, et al. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2. Cancer Lett. 2018 Oct 10;434:42-55.|[3]Hao Let al. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021 May;53 (5) :875-884.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
R2997-80E-HRP 100 µL
ROC1 (Regulator of Cullins 1, Protein ZYP, RING Box 1, RING Box Protein 1, Ringbox Protein 1, Rbx, 1, RING Finger Protein 75, RNF75, ZYP Protein, Hrt1) (HRP)
Sign In for Pricing
View Details 