I-287
I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant -induced inflammation in mice and can be used for inflammation/immunology research[1].
Product Specifications
CAS Number
2014368-93-3
UNSPSC
12352005
Target
ERK; Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/i-287.html
Purity
99.36
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CN=C(N2CCN(C(C)(C2)C)C(C3=CC(N=C(C4=CC=C(C(F)=C4)Cl)C=C5C(C)(C)C)=C5O3)=O)C=C1)O
Molecular Formula
C30H30ClFN4O4
Molecular Weight
565.04
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR2
Available Sizes
Frequently Asked Questions
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