I-287

I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808) -induced inflammation in mice and can be used for inflammation/immunology research[1].

Product Specifications

CAS Number

[2014368-93-3]

UNSPSC

12352005

Target

ERK; Protease Activated Receptor (PAR)

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/i-287.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CN=C(N2CCN(C(C)(C2)C)C(C3=CC(N=C(C4=CC=C(C(F)=C4)Cl)C=C5C(C)(C)C)=C5O3)=O)C=C1)O

Molecular Formula

C30H30ClFN4O4

Molecular Weight

565.04

References & Citations

[1]Avet C, et.al. The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects. Commun Biol. 2020 Nov 27;3 (1) :719.