DS28120313
DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM[1].
Product Specifications
CAS Number
2146177-09-3
UNSPSC
12352005
Target
Ferroportin; Hepcidin
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ds28120313.html
Concentration
10mM
Purity
98.00
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(NN=C1C2CC2)=C1C3=CC(NC(OC)=O)=C(C=NN4)C4=C3
Molecular Formula
C16H17N5O2
Molecular Weight
311.34
References & Citations
[1]Fukuda T, et al. Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives. Bioorg Med Chem Lett. 2017 Dec 1;27 (23) :5252-5257.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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