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IL-17 modulator 4

IL-17 modulator 4 is a proagent of IL-17 modulator 1. IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome[1][2].

Product Specifications

CAS Number

2446803-65-0

UNSPSC

12352005

Target

Interleukin Related

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/il-17-modulator-4.html

Concentration

10mM

Purity

99.00

Solubility

DMSO : 300 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=NN1C(C)C)N[C@H](C(NC2=CC=C(C3=C(C)NN=C3C)C=C2)=O)C(C4CC4)C5CC5

Molecular Formula

C27H34N6O2

Molecular Weight

474.60

References & Citations

[1]Kevin Neil Dack, et al. Amino-acid anilides as small molecule modulators of il-17. WO2020127685A1.|[2]Zhang B, et al. Small molecule modulators of IL-17A/IL-17RA: a patent review (2013-2021) . Expert Opin Ther Pat. 2022 Nov;32 (11) :1161-1173. |[3]Andrews MD, et al., Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases. J Med Chem. 2022 Jul 14;65 (13) :8828-8842.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IL-17

Available Sizes

Frequently Asked Questions

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