N4-Benzoyl-5'-O- (4,4'-dimethoxytrityl) -2'-deoxycytidine

N4-Benzoyl-5'-O- (4,4'-dimethoxytrityl) -2'-deoxycytidine (5'-O-DMT-N4-Bz-dC) can be used for synthesis oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. N4-Benzoyl-5'-O- (4,4'-dimethoxytrityl) -2'-deoxycytidine is an useful tool for probing enzyme-catalyzed cleavage processes in DNA[1].

Product Specifications

CAS Number

[67219-55-0]

Product Name Alternative

5'-O-DMT-N4-Bz-dC

UNSPSC

12352005

Hazard Statement

H340, H350

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n4-benzoyl-5-o-4-4-dimethoxytrityl-2-deoxycytidine.html

Concentration

10mM

Purity

99.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N=C(NC(C1=CC=CC=C1)=O)C=C2)N2[C@H]3C[C@H](O)[C@@H](COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)O3

Molecular Formula

C37H35N3O7

Molecular Weight

633.69

Precautions

H340, H350

References & Citations

[1]James W Gaynor, et al. Synthesis of the 3'-thio-nucleosides and subsequent automated synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate linkage. Nat Protoc. 2007;2 (12) :3122-35.