ICA-069673

ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM) . ICA-069673 also decreases the global intracellular Ca (2+) concentration in DSM cells[1][2].

Product Specifications

CAS Number

[582323-16-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ICA-069673.html

Purity

99.20

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1=CN=C(Cl)N=C1)C2=CC=C(F)C(F)=C2

Molecular Formula

C11H6ClF2N3O

Molecular Weight

269.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Provence A, et al. The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther. 2015 Sep;354 (3) :290-301.