Topoisomerase IIα-IN-8
Topoisomerase IIα-IN-8 (compound 15) is a weak human DNA topoisomerase IIa (htIIa) inhibitor, with an IC50 of 462 ± 38.0 μM[1].
Product Specifications
CAS Number
[1251578-67-2]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-iiα-in-8.html
Purity
97.68
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C=C1)NC2=NC3=C(N=CN3)C(N4CCOCC4)=N2
Molecular Formula
C15H15FN6O
Molecular Weight
314.32
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Barbara Pogorelčnik, et al. Discovery of Mono- and Disubstituted 1H-Pyrazolo[3,4]pyrimidines and 9H-Purines as Catalytic Inhibitors of Human DNA Topoisomerase II. ChemMedChem, 2015.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Dedicated for Diverse Library
Clinical Information
No Development Reported
Isoform
Topo II
Curated Selection
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