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Topoisomerase IIα-IN-8

Topoisomerase IIα-IN-8 (compound 15) is a weak human DNA topoisomerase IIa (htIIa) inhibitor, with an IC50 of 462 ± 38.0 μM[1].

Product Specifications

CAS Number

1251578-67-2

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-iiα-in-8.html

Purity

97.68

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(C=C1)NC2=NC3=C(N=CN3)C(N4CCOCC4)=N2

Molecular Formula

C15H15FN6O

Molecular Weight

314.32

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Barbara Pogorelčnik, et al. Discovery of Mono- and Disubstituted 1H-Pyrazolo[3,4]pyrimidines and 9H-Purines as Catalytic Inhibitors of Human DNA Topoisomerase II. ChemMedChem, 2015.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Dedicated for Diverse Library

Clinical Information

No Development Reported

Isoform

Topo II

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