TD-198946
TD-198946, a thienoindazole derivative, is a potent chondrogenic agent.
Product Specifications
CAS Number
364762-86-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/TD-198946.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : ≥ 28 mg/mL
Smiles
O=C(C1=C2CCC3=C(N(C)N=C3)C2=C(OC4=CC=C(OCC5=NC6=CC=CC=C6C=C5)C=C4)S1)N
Molecular Formula
C27H22N4O3S
Molecular Weight
482.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Yano F, et al. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013 May;72 (5) :748-53.|[2]Yano F, et al. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis. 2014 Nov;73 (11) :2062-4.|[3]Yano F, et al. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials. 2013 Jul;34 (22) :5581-7.|[4]Kobayashi M, Chijimatsu R, Hart DA, et al. Evidence that TD-198946 enhances the chondrogenic potential of human synovium-derived stem cells through the NOTCH3 signaling pathway. J Tissue Eng Regen Med. 2021;15 (2) :103-115.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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