Lanicemine (dihydrochloride)

Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively) . Antidepressant effects[1].

Product Specifications

CAS Number

[153322-06-6]

Product Name Alternative

AZD6765 (dihydrochloride) ; ARL 15896AR

UNSPSC

12352005

Hazard Statement

H301

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lanicemine-dihydrochloride.html

Purity

99.94

Solubility

DMSO : 240 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

N[C@H](C1=CC=CC=C1)CC2=CC=CC=N2.Cl.Cl

Molecular Formula

C13H16Cl2N2

Molecular Weight

271.19

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19 (9) :978-85.