Lanicemine (dihydrochloride)
Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively) . Antidepressant effects[1].
Product Specifications
CAS Number
153322-06-6
Product Name Alternative
AZD6765 (dihydrochloride) ; ARL 15896AR
UNSPSC
12352005
Hazard Statement
H301
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lanicemine-dihydrochloride.html
Purity
99.94
Solubility
DMSO : 240 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
N[C@H](C1=CC=CC=C1)CC2=CC=CC=N2.Cl.Cl
Molecular Formula
C13H16Cl2N2
Molecular Weight
271.19
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19 (9) :978-85.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NMDA Receptor
Available Sizes
Frequently Asked Questions
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