Diphenhydramine-d5 (hydrochloride)
Product Specifications
UNSPSC Description
Diphenhydramine-d5 (hydrochloride) is the deuterium labeled Diphenhydramine hydrochloride. Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB)[1][2].
Target Antigen
Endogenous Metabolite; Histamine Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
Field of Research
Inflammation/Immunology; Endocrinology
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CN(C)CCOC(C1=CC=CC=C1)C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H].Cl
Molecular Weight
296.85
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Simons FE. H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994;10(5):350-380.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Clinical Information
No Development Reported
CAS Number
1219795-16-0
Available Sizes
Curated Selection
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