L-Phenylalanine-d5
L-Phenylalanine-d5 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S) -2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
Product Specifications
CAS Number
[56253-90-8]
Product Name Alternative
(S) -2-Amino-3-phenylpropionic acid-d5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel; Endogenous Metabolite; iGluR
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Concentration
10mM
Purity
99.90
Solubility
H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC([C@@H](N)CC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=O
Molecular Formula
C9H6D5NO2
Molecular Weight
170.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
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