Isojacareubin

Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis[1][2][3].

Product Specifications

CAS Number

[50597-93-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Bacterial; PKC; SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/isojacareubin.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(OC3=C1C=CC(O)=C3O)C(C=CC(C)(C)O4)=C4C=C2O

Molecular Formula

C18H14O6

Molecular Weight

326.30

Precautions

H315, H319, H335

References & Citations

[1]Kyoko Ishiguro, et al. An isopentenylated flavonol from Hypericum japonicum. Phytochemistry. 1993. 32 (6), 1583-1585.|[2]Khan A, et al. Discovery of Isojacareubin as a covalent inhibitor of SARS-CoV-2 main protease using structural and experimental approaches. J Med Virol. 2023 Feb;95 (2) :e28542.|[3]Yuan X, et al. Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. Sci Rep. 2015 Aug 6;5:12889.