5Z-7-Oxozeaenol

5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively.

Product Specifications

CAS Number

[253863-19-3]

Product Name Alternative

FR148083; L783279; LL-Z 1640-2

UNSPSC

12352005

Hazard Statement

H301

Target

Antibiotic; MAP3K; VEGFR

Type

Natural Products

Related Pathways

Anti-infection; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/5Z-7-Oxozeaenol.html

Purity

99.60

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

O=C(O[C@@H](C)C/C=C\1)C2=C(O)C=C(OC)C=C2/C=C/C[C@H](O)[C@H](O)C1=O

Molecular Formula

C19H22O7

Molecular Weight

362.37

Precautions

H301

References & Citations

[1]Ninomiya-Tsuji J, et al. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J Biol Chem. 2003 May 16;278 (20) :18485-90.|[2]Dakas PY, et al. Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors. Angew Chem Int Ed Engl. 2007;46 (36) :6899-902.|[3]Takehana K, et al. A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner. Biochem Biophys Res Commun. 1999 Apr 2;257 (1) :19-23.