5Z-7-Oxozeaenol
5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively.
Product Specifications
CAS Number
253863-19-3
Product Name Alternative
FR148083; L783279; LL-Z 1640-2
UNSPSC
12352005
Hazard Statement
H301
Target
Antibiotic; MAP3K; VEGFR
Type
Natural Products
Related Pathways
Anti-infection; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/5Z-7-Oxozeaenol.html
Purity
99.60
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
O=C(O[C@@H](C)C/C=C\1)C2=C(O)C=C(OC)C=C2/C=C/C[C@H](O)[C@H](O)C1=O
Molecular Formula
C19H22O7
Molecular Weight
362.37
Precautions
H301
References & Citations
[1]Ninomiya-Tsuji J, et al. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J Biol Chem. 2003 May 16;278 (20) :18485-90.|[2]Dakas PY, et al. Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors. Angew Chem Int Ed Engl. 2007;46 (36) :6899-902.|[3]Takehana K, et al. A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner. Biochem Biophys Res Commun. 1999 Apr 2;257 (1) :19-23.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MAP3K7/TAK1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Available Sizes
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