HPK1-IN-4
HPK1-IN-4 (comp 22) is a HPK1 (MAPK41) inhibitor (IC50 of 0.061 nM) as preclinical immunoresearch tool compound[1].
Product Specifications
CAS Number
2739844-28-9
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-4.html
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic; adjust pH to 4 with HCl)
Smiles
COC1=C(NC2=NC=C(C(N)=O)C(NC3=CC=CC=C3CO)=N2)C=C4CN(C)CCC4=C1
Molecular Formula
C23H26N6O3
Molecular Weight
434.49
References & Citations
[1]Brandon A Vara, et al. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. ACS Med Chem Lett. 2021 Mar 19;12 (4) :653-661.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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