1-Deoxynojirimycin (hydrochloride)

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

Product Specifications

CAS Number

[73285-50-4]

Product Name Alternative

Duvoglustat (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Antibiotic; Bacterial; Glycosidase; PI3K

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/1-deoxynojirimycin-hydrochloride.html

Purity

98.0

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O.[H]Cl

Molecular Formula

C6H14ClNO4

Molecular Weight

199.63

Precautions

H315, H319, H320

References & Citations

[1]Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21 (11) . pii: E1600.|[2]Chaluntorn Vichasilp, et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232.|[3]Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20 (12) :21700-14.