Guanidinoethyl sulfonate

Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM) . Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury[1][2][3].

Product Specifications

CAS Number

[543-18-0]

Product Name Alternative

Taurocyamine

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/guanidinoethyl-sulfonate.html

Purity

99.91

Solubility

H2O : 41.67 mg/mL (ultrasonic)

Smiles

N=C(NCCS(=O)(O)=O)N

Molecular Formula

C3H9N3O3S

Molecular Weight

167.19

Precautions

H302, H312, H332

References & Citations

[1]Sergeeva OA, et al. Guanidinoethyl sulphonate is a glycine receptor antagonist in striatum. Br J Pharmacol. 2002 Nov;137 (6) :855-60.|[2]Igarashi H, et al. Guanidinoethane sulfate is neuroprotective towards delayed CA1 neuronal death in gerbils. Life Sci. 1995;56 (14) :1201-6.|[3]K Ejiri, et al. Effect of guanidinoethyl sulfonate on taurine concentrations and fetal growth in pregnant rats. Biol Neonate. 1987;51 (4) :234-40.