Monoethyl fumarate

Monoethyl fumarate is the monoethyl ester form of Fumaric acid (HY-W015883) . Monoethyl fumarate is the activator for Nrf2. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material[1][2].

Product Specifications

CAS Number

[2459-05-4]

UNSPSC

12352211

Hazard Statement

H315, H317, H319, H335

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/monoethyl-fumarate.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

CCOC(/C=C/C(O)=O)=O

Molecular Formula

C6H8O4

Molecular Weight

144.13

Precautions

H315, H317, H319, H335

References & Citations

[1]Ausama Atwan, et al. Oral Fumaric Acid Esters for Psoriasis. Cochrane Database Syst Rev. 2015 Aug 10;2015 (8) :CD010497.|[2]Brennan MS, et al., Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro. PLoS One. 2015 Mar 20;10 (3) :e0120254.