Monoethyl fumarate
Monoethyl fumarate is the monoethyl ester form of Fumaric acid (HY-W015883) . Monoethyl fumarate is the activator for Nrf2. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material[1][2].
Product Specifications
CAS Number
[2459-05-4]
UNSPSC
12352211
Hazard Statement
H315, H317, H319, H335
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/monoethyl-fumarate.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
CCOC(/C=C/C(O)=O)=O
Molecular Formula
C6H8O4
Molecular Weight
144.13
Precautions
H315, H317, H319, H335
References & Citations
[1]Ausama Atwan, et al. Oral Fumaric Acid Esters for Psoriasis. Cochrane Database Syst Rev. 2015 Aug 10;2015 (8) :CD010497.|[2]Brennan MS, et al., Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro. PLoS One. 2015 Mar 20;10 (3) :e0120254.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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